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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MKL1 All Species: 24.24
Human Site: S133 Identified Species: 66.67
UniProt: Q969V6 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q969V6 NP_065882.1 931 98919 S133 E Q P A S H E S Q G S V P S P
Chimpanzee Pan troglodytes XP_001146728 1112 120651 S205 D Q P A S Q E S Q G S A A S P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_859224 925 97930 S133 E Q P A S H E S Q S S V P S P
Cat Felis silvestris
Mouse Mus musculus Q8K4J6 964 102528 S168 E Q P A S H E S Q G S V P S P
Rat Rattus norvegicus Q8R5I7 938 101853 Q166 R D G L S P D Q A R S E D P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505409 1041 113389 S205 D Q P A S Q D S Q G S A A S P
Chicken Gallus gallus XP_416243 1105 117878 S263 E Q P A S H E S Q G S V P S P
Frog Xenopus laevis Q8AYC2 936 103220 L156 D E D S S D A L S P E Q P A S
Zebra Danio Brachydanio rerio XP_001333839 986 108377 S197 E Q P A S Q E S Q G S A A S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 42.8 N.A. 90 N.A. 82.3 37.6 N.A. 44.1 63.4 46.4 38.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 55.4 N.A. 92.6 N.A. 86 52.3 N.A. 55.8 69 58.7 50.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 73.3 N.A. 93.3 N.A. 100 13.3 N.A. 66.6 100 13.3 80 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 80 N.A. 93.3 N.A. 100 20 N.A. 80 100 40 80 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 78 0 0 12 0 12 0 0 34 34 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 34 12 12 0 0 12 23 0 0 0 0 0 12 0 0 % D
% Glu: 56 12 0 0 0 0 67 0 0 0 12 12 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 12 0 0 0 0 0 0 67 0 0 0 0 0 % G
% His: 0 0 0 0 0 45 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 12 0 0 0 12 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 78 0 0 12 0 0 0 12 0 0 56 12 78 % P
% Gln: 0 78 0 0 0 34 0 12 78 0 0 12 0 0 12 % Q
% Arg: 12 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % R
% Ser: 0 0 0 12 100 0 0 78 12 12 89 0 0 78 12 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 45 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _